The neurologic phenotype in SCA8 BAC enlargement but not BAC Command lines shown the pathogenicity from the (CTG-CAG)n growth. Furthermore, the expression of noncoding (CUG)n growth ATXN8OS transcripts and the invention of intranuclear polyglutamine inclusions advised that SCA8 pathogenesis involves poisonous attain-of-operate mechanisms at both of… Read More